Crossover GEE

Dynamic and Reproducible Tutorial

Pablo Rogers and Sérgio Georgeto

January 27, 2026

Abstract

This dynamic and reproducible tutorial is part of a broader research initiative on utilizing Generalized Estimating Equation (GEE) in crossover studies within the context of randomized clinical trials related to physiotherapy and rehabilitation (Georgeto & Rogers, 2024a, 2024b; Rogers & Georgeto, 2024). The primary goal is to provide a comprehensive application tutorial in the R environment, demonstrating best practices for analyzing crossover designs using GEE.

This project adopts open science principles and reproducible research practices as outlined by Limongi & Rogers (2025a), Limongi & Rogers (2025b), and Rogers & Limongi (2025), ensuring transparency, accessibility, and replicability of all analyses and results. The tutorial integrates theoretical foundations with practical implementation, offering researchers and practitioners a hands-on guide for conducting rigorous statistical analyses in crossover clinical trials.

Keywords: Quantitative Methods, Generalized Estimating Equation, GEE, Crossover Trials, Crossover Studies, Reproducible Research, Open Science.

How to cite this project?

Rogers, P., & Georgeto, S. M. (2024). Utilizing GEE in Crossover Studies. https://doi.org/10.17605/OSF.IO/MU67G

Georgeto, S. M., & Rogers, P. (2024a). Applying ANOVA in Crossover Trials. https://doi.org/10.17605/OSF.IO/3RXF2

Georgeto, S. M., & Rogers, P. (2024b). Quantitative Methods in Crossover Studies. https://doi.org/10.17605/OSF.IO/Q2MGK

Limongi, R., & Rogers, P. (2025a). Open Science in Three Acts: Foundations, Practice, and Implementation - First Act. BAR - Brazilian Administration Review, 22(1), e250079. https://doi.org/10.1590/1807-7692bar2025250079

Limongi, R., & Rogers, P. (2025b). Open Science in Three Acts: Foundations, Practice, and Implementation - Second Act. BAR - Brazilian Administration Review, 22(2), e250116. https://doi.org/10.1590/1807-7692bar2025250116

Rogers, P., & Georgeto, S. M. (2024). Utilizing GEE in Crossover Studies. https://doi.org/10.17605/OSF.IO/MU67G

Rogers, P., & Limongi, R. (2025). Open Science in Three Acts: Foundations, Practice, and Implementation - Third Act. BAR - Brazilian Administration Review, 22(3), e250162. https://doi.org/10.1590/1807-7692bar2025250162